BIOMED PRIVATE LIMITED

Peda Hib

The New Generation Conjugate vaccine. 
(Haemophilus type b conjugate vaccine)
Haemophilus influenzae type b bacteria causes serious disease like meningitis in 60% cases and pneumonia, epiglotitis, pericarditis, cellulitis etc in 40% cases. The mortality rate with meningitis is quite high. Post neurological disorders have been seen in many cases after recovery. Under these circumstances vaccine assumes its importance.
DESCRIPTION : 
Peda Hib™ is a highly purified vaccine prepared from capsular polysaccharide (polyribitol phosphate) short named PRP, covalently
bonded to tetanus toxoid protein. Addition of lactose and freeze-drying has resulted in a highly stable vaccine.
This vaccine induces ‘T’- cell dependent immune response in infants that is essential for appropriate initial humoral antibody response and priming for booster effects (anamnestic response) of subsequent vaccinations. Such immune response is lacking in vaccines prepared from unconjugated PRP. Peda Hib™ has been manufactured using the latest technology to remove contaminants eg. L.P.S. pyrogens to make it the least reactogenic but highly immunogenic vaccine. Thus Peda Hib™ is the latest generation vaccine of the best quality in its class. 
Peda Hib™ meets the stringent WHO standards for the manufacture of Biological Substances and WHO Technical Report Series, No. 897, (2000).
COMPOSITION : 
Each Single dose of vaccine contains :

Particulars	Quantity
Purified Polysaccaharide of Haemophilus influenzae type b (PRP)	10 mcg
Tetanus Toxoid protein	20 mcg
Lactose (I.P.) (Stabilizer)	2 mg
Sucrose (I.P.)	42.5 mg
Thimerosal (I.P.) ( Preservative)	0.05 mg

INDICATIONS :
Peda Hib™ is indicated for the prevention, in children from 6 weeks to 5 years age, of invasive diseases caused byHaemophilus influenzae type b e.g. Meningitis, cellulitis, epiglotitis. In no case can the tetanus protein contained in Peda Hib™ replace the routine tetanus vaccination.
PRESENTATION :
Single dose vial freeze dried white pellet / powder form with sterile water for injection (I.P.).
DOSAGE AND ADMINISTRATION : 
Reconstitute Peda Hib™ lyophilisate with water for injection, shake gently until lyophilisate is dissolved completely. Administer by intramuscular route.

Age at start of immunization	No. of doses ( interval of 1-2 months)	Booster at
6 weeks to 6 months	3	15-18 months
Between 6 to 12 months	2	15-18 months
Between 1 to 5 years	1	Nil

Children below 24 months, who have invasive Hib disease may not develop adequate Hib antibody concentrations and remain at risk for a second episode of disease. Vaccination of these children is recommended according to current age, ignoring previous Hib doses.

CONTRA- INDICATION : 
• Children, with known hypersensitivity to any of the components of the vaccine. 
• Children having shown signs of hypersensitivity to previous injection of this vaccine.

• Children with febrile illness should be called for vaccination after recovery.